How do we know this?
The spread of the plague has been better understood in recent decades thanks to modern science and the sequencing of genomes. The bacterium Yersinia pestis has been sequenced, and modern science can detect it from bones of the long-dead. In many cases, those bones are easier to identify because the plague killed so many so fast that the corpses were thrown into mass graves quickly. In fact, the approach of the plague did prompt preparation: the mass graves in London were dug before the plague actually arrived. (The illustration shows a mass grave of plague victims in France.)
Therefore, by examining skeletons from different eras, we can track the spread and durability of the plague, which was endemic in Europe after the mid-14th century appearance. Plague returned approximately every decade or so for centuries. Whatever the cause (see the link in the first paragraph), folk realized they should try to stay away from those who were infected. This led to quarantining when news of a plague resurgence came to a community. You could either barricade yourself in your house or escape the town. In 1377, the town of Ragusa on the Adriatic initiated the first wide-spread, mandatory quarantine. In the second half of the 1400s, quarantines were common around the Mediterranean, whose warm weather and coastal ports allowed plague to thrive and spread.
Ragusa actually had a reputation for doctors. If you search for Ragusa on a map today, it will show you a city in southern Sicily, not on the coast of the Adriatic. That's because it's got a different name now: Dubrovnik. Let's talk about its medieval history tomorrow.
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