Mesih was Grand Admiral of the Ottoman navy and had great successes. He negotiated (successfully) with the rebelling Janissaries when they occupied the palace, angry at the sultan's imprisoning of one of their favorites. He negotiated a compromise with Sultan Bayezid II's rival half-brother, Cem, who had teamed up with the Knights Hospitallers in Rhodes against Bayezid. (The illustration shows Mesih at Rhodes.)
For some reason, however, he fell out of favor with Bayezid in 1485 and was dismissed from his position as vizier at court, being made simply governor of Filibe (once called Philippopolis, now Plovdiv, the second-largest city in Bulgaria). He was shortly exiled (essentially) to Kaffa, on the northern coast of the Black Sea.
His exile did not last forever. In 1497 he was made sanjak bey, military and administrative leader of the port city Akkerman (now Bilhorod-Dnistrovskyi in southern Ukraine). While there he halted a Poolish invasion of Moldavia, sending several Polish nobles to Bayezid as tribute.
In 1499 he went on pilgrimage to Mecca, an excuse for leaving his position which gave him a reason to visit Constantinople and try to get back to a position at court. Fortunately, the Venetians were fighting the Ottomans again, and his previous naval experience against the Venetians led to being re-named vizier, and then in 1501 Grand Vizier.
Things were looking up again, but that same year the Venetians attacked Lesbos to get it back from the Ottomans. Bayezid, unhappy that the Venetians felt able to make such a bold move against him, in a fit of pique struck Mesih. We don't know how serious the injury may have been, but soon after, after supervising putting out a fire in a Constantinople suburb, Mesih was supposedly injured. He died in November 1501. He was buried in the Murat Pasha Mosque in Constantinople, begun by his brother Hass Murad Pasha and completed by Mesih himself.
Now for something completely different. The illustration above, a painting of Mesih addressing Rhodes, was painted by an eyewitness of that negotiation! His name was Guillaume Caoursin, and we're going to talk about him next.