Procopius mentions it in 541, writing the it started at Pelusium, a busy port just east of the Nile delta. Contemporary writers claimed it came to Constantinople on grain ships from Egypt that carried rats. (Egypt was a large exporter of grain to the Roman Empire.) Justinian himself became ill early on, but recovered.
Procopius claimed that at its height, the plague was killing 10,000 per day; modern scholars agree that it may have been as high as 5,000 per day at its peak. This is an exaggeration, but the following from his Anecdota (also called "Secret History") may not have been:
When pestilence swept through the whole known world and notably the Roman Empire, wiping out most of the farming community and of necessity leaving a trail of desolation in its wake, Justinian showed no mercy towards the ruined freeholders. Even then, he did not refrain from demanding the annual tax, not only the amount at which he assessed each individual, but also the amount for which his deceased neighbors were liable.
(On the other hand, Procopius was not always kind in his assessment of Justinian or the people around him.)
The plague had results that we have seen before: farmers died, grain prices rose. Laborers took advantage of the shortage of workers and demanded higher wages.
Justinian passed laws trying to keep the economy working. In March 542 Justinian wrote a law to prop up the banks, writing that this was amid the "encircling presence of death" that had "spread to every region." In 544 he imposed price and wage controls, writing that the "chastening which has been sent by God’s goodness’ should have made workers ‘better people’ but instead ‘they have turned to avarice." Gold coins were still minted at this time, but they were lighter than previously.
Tomorrow I'll share some first-hand accounts of some who lived through it
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